Overweight & Obesity

Overweight and obesity (ICD-10 code E66) is a chronic, relapsing condition characterized by excess body fat that increases the risk of serious health problems including type 2 diabetes, cardiovascular disease, certain cancers, and sleep apnea. According to the CDC, about 42% of U.S. adults have obesity and approximately 74% are overweight or have obesity.

BMI Thresholds

  • Underweight: BMI < 18.5
  • Normal weight: BMI 18.5 – 24.9
  • Overweight: BMI 25.0 – 29.9
  • Obesity class I: BMI 30.0 – 34.9
  • Obesity class II: BMI 35.0 – 39.9
  • Obesity class III (severe): BMI ≥ 40.0

Why It Matters

Obesity is associated with significantly elevated risk of type 2 diabetes, hypertension, dyslipidemia, coronary artery disease, stroke, non-alcoholic fatty liver disease, obstructive sleep apnea, osteoarthritis, and certain cancers. It is also a leading contributor to disability-adjusted life years lost in the United States.

Treatment Options

Effective treatment combines behavioral, nutritional, and where medically appropriate, pharmacologic interventions. GLP-1 receptor agonists (such as semaglutide) and dual GIP/GLP-1 receptor agonists (such as tirzepatide) have demonstrated significant and sustained weight reduction in major randomized controlled trials (STEP 1, SURMOUNT-1) of the FDA-approved branded products.

AvataCore connects eligible adults with U.S.-licensed clinicians who, when appropriate, may prescribe compounded GLP-1 medications prepared by state-licensed U.S. compounding pharmacies. Compounded medications are not FDA-approved.

Available GLP-1 Therapies

When to Talk to a Provider

Adults with a BMI of 30 or higher, or a BMI of 27 or higher with a weight-related condition (such as type 2 diabetes, hypertension, high cholesterol, or sleep apnea), may benefit from a clinical evaluation for GLP-1 therapy. Medical guidance is essential — GLP-1 medications have specific contraindications and require ongoing monitoring.

See if You Qualify

Take a free 2-minute eligibility quiz. If approved, a U.S.-licensed clinician will review your case and determine an appropriate treatment plan.

Start Eligibility Quiz →

Medical disclaimer: This content is for general educational purposes only and is not medical advice. Compounded medications are not FDA-approved. Always consult a licensed healthcare provider regarding diagnosis or treatment. See our safety information for full details.